Some US cities are dramatically worse for allergy sufferers than others โ due to geography, climate, and the types of plants that dominate the landscape. Cities in the South and Midwest consistently top the lists for highest pollen counts and longest seasons.
Peak season: Year-round โ varies by city and allergen type
Most affected regions: South, Midwest, Southeast, Mid-Atlantic
Common symptoms: Sneezing, itchy eyes, runny nose, congestion, asthma flares.
Consistently ranked among the worst: Wichita KS, Louisville KY, Oklahoma City OK, Dayton OH, McAllen TX, Atlanta GA, and Jackson MS. These cities combine high pollen volume, long seasons, and weather patterns that keep pollen airborne.
The worst allergy cities combine several factors: warm climate that extends the season, local vegetation producing highly allergenic pollen (oak, ragweed, cedar), flat terrain and wind that spreads pollen widely, and high humidity that also promotes mold growth.
Cities with lower pollen counts tend to be coastal, high-altitude, or in drier climates: Portland OR (rainy climate washes pollen), San Francisco CA (cool marine layer), Denver CO (shorter season), and cities in Alaska or the desert Southwest (low plant diversity).